CAS : 1824-81-3
formula : C6H8N2
molecular weight : 108.14
boiling point : 208-209 ° C
melting point : 40-45 ° C
Chinese name : 2-amino-6-methyl-pyridine; 2-amino-6-methyl-N benzene; 2-amino-6-Picoline
title : 6-methyl-2-Pyridinamine; 2-amino-6-methyl-pyridin; 2-amino-6-methylpyridine; 6-methyl-2-pyridinamin; 2-amino-6-picoline
traits Description : white or slightly yellow crystal. 41 ° C melting point, boiling point, 208-209 ° C and relative density of 1.0432 (45 / 4 ° C). Vulnerable to dissolve in water, soluble in alcohol; Ether; Acetone; Benzene, most organic solvents. There hygroscopicity.
production methods : by 2-methylpyridine amination derived. Qualcomm will liquid ammonia tank into the reaction by adding high iron nitrate, stirring slowly under graded by adding small pieces of metal sodium, plus BI continue stirring 3h. Natural ammonia excretion to the reaction solution was diluted Slurry, sodium in liquid ammonia. Will anhydrous ammonia by adding sodium xylene, stirring warming, in addition to steamed residual ammonia. The temperature rose to 120 ° C 71/92 2-methylpyridine, plus complete, 124-129 ° Cmaintain 10h. 90-100 ° C in slowly adding suitable water hydrolysis, hydrolysis End stirring half-hour, get a static-xylene, xylene recovery distillation, vacuum distillation then collect 90-120 ° C (1.33-2.67 kPa) fraction, or 2-amino-6 - Picoline. The yield of 72%.
purposes : pharmaceutical intermediates. For the production of nalidixic acid, also used in organic synthesis, manufacture dyes and photographic reagent.
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