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Quinidine
drug name : quinidine

English : Quinidine

Alias : quinidine , quinidine sulfate
Foreign Name : Quinidine
pharmacological effects and purposes :
direct inhibition of Na + influx, significantly prolong cardiac refractory period. The inhibitory effect of self-discipline and conduction and thus contribute to the elimination of reentry. Myocardial reduce stress and increase the threshold to flutter. There is also inhibited Ca2 + influx and block blood vessels? Receptors, negative inotropic effect and vascular expansion, dual impact of significantly lower blood pressure. Drug early plasma concentration is low, the main performance of nerve indirect role that the anti-cholinergic (atropine-like); When the plasma concentration steady state, direct dominant role. For atrial fibrillation and atrial flutter -- before conversion to the preparation and prevention of recurrence after sinus rhythm; The reduction or prevention of paroxysmal supraventricular tachycardia and ventricular tachycardia recurrence.
indications :
1. Mainly for paroxysmal tachycardia, atrial fibrillation, as Bo. 2. Prevention of ventricular tachycardia and right atrioventricular nodal reentrant tachycardia. 3. It can also prevent the symptoms of room and room early stage.
usage and usage :
?atrial fibrillation or atrial flutter cardioversion : 0.2g first oral observed an hour, without adverse reaction, the next day to 0.2g, each a two-hour meeting, serving a total of five meeting; if it still invalid, and no adverse reaction, on the 3rd to 0.39, every two hours a time, serving a total of five times. Yet conversion to sinus rhythm can be reused 1, 0.4 g every two hours a time, serving a total of five times, so if we continue invalid, as a failure. From the hospital, the maintenance doses 0.2g, the daily 3 ~ 4 or sustained-release capsules 0.3 g, 2 times daily. The frequent pieces or pieces Room Premature : Oral 0.2g, the daily 3 ~ 4 or sustained-release capsules 0.3 g, 2 times daily. ?a
. Oral : Article 1, each 0.2g, each a two-hour meeting, five consecutive times; If invalid with no obvious toxicity, on the 2nd of each to 0.39, 0.4 g each on the 3rd, every two hours a time, continuous 5. Daily total general should not exceed 2g. Resume normal rhythm, changed to maintain volume, 0.2 ~ 0.4 g per day. If even three ~ served on the 4th ineffective or toxic reactions, and we should stop. 2. Intravenous : used when absolutely necessary and required under the guardianship electrocardiogram. Each of 0.25 to 5% glucose solution diluted intravenous slow to 50ml. Each child per kilogram body weight 2mg.
adverse reactions :
?nausea, diarrhea, abdominal pain, vomiting and anorexia, tinnitus, hearing loss, blurred vision, neurotic disorders, such as delirium. ?rash, fever, thrombocytopenia, anemia, leukopenia and granulomatous hepatitis. ?arrhythmia add : frequent premature ventricular contractions, ventricular tachycardia and ventricular fibrillation, reversing ventricular tachycardia, a serious sinus bradycardia, sinus block, or even sinus cardioplegia, block heavier. ?rhythm to normal, shedding induced thrombosis produce systemic embolism. ?impaired myocardial contractility and hypotension.
Note :
?with digoxin, quinidine can reduce digoxin by renal excretion increased digoxin in plasma, the joint application, it should be reduced to the amount of digoxin. ?and vasodilator or lowering blood pressure and medicine, the role of the goods increase. ?with phenytoin, phenobarbital, rifampin used, the materials can reduce serum concentration; If used with cimetidine and may raise blood concentration. ?combination with anticoagulants can blood prothrombin further reduced, the need to adjust dosage. ?since the materials have anticholinergic effect so atrioventricular node Chuan I. accelerated. Therefore, in the treatment of atrial fibrillation and atrial flutter, should have served digitalis drugs to prevent ventricular rate accelerated trigger heart failure. ?during treatment should be measured regularly QRS and QT time. QRS time when >25% ~ 35%, or QT interval >500 QTU milliseconds, reductions or adjustments to the treatment. ?with amiodarone and sotalol or other extension of the QT interval and drug use, special care should be best avoided. ?after serving nausea, vomiting, diarrhea, headache, tinnitus, visual impairment and other adverse reactions, specific medication after physique who have difficulty in breathing, cyanosis, ventricular fibrillation and ventricular asystole. ?for correcting atrial fibrillation, atrial flutter, should be accorded capacity of digitalis, so after the change of heart rhythm accelerated, resulting in heart failure. ?each administration, should examine the heart rate and blood pressure changes, and avoid overnight delivery. The larger dose of sun, the night should also pay attention to heart rate and blood pressure. K. patients suffering from atrial fibrillation, in the course of administration, when transferred to normal rhythm may be triggered off atrial thrombus, have embolic lesions, such as cerebral embolism, mesenteric artery embolization, should be closely observed. Published Applications for the indication quinidine, but low blood pressure or in a state of shock patients should first talk about hypertension, correct shock, and then reuse. If the blood pressure is due to tachycardia, cardiac output caused by small, one should mention hypertension, the use of quinidine side. Never too serious damage to the myocardium of patients and pregnant women hanged. The mindset of intravenous often cause severe hypotension, a greater risk, and can lead to shock and even death, need special attention. Quinidine martyrs and the general toxicity and dose. But for the allergy products, though with a small, serious reactions may occur.
specifications : tablet : 0.2g (sulfate), quinidine gluconate each Injection 0.5g (10ml).


categories : antiarrhythmic \ anti-tachycardia \ Class I -- sodium channel blockers
Warning:The information is only as a reference for new drug researcher and the patients or doctors can't use it as prescription basis!
Notice:Each item can have many explanations from different angels. If you want grasp the item comprehensively,please see below "more details data".
Structure:
Please see below "More Detailed Data"
More Detailed Data:
1) Quinidine Sulfate
2) quinidine
3) quinidine
4) hydroquinidine;dihydroquinidine
5) Dihydroquinidine
6) quindine
7) Sulfuric acid;Sulfuric acid, fuming;acide sulfurique
8) sulfuric acid
9) sulfuric acid
10) sulfuric acid
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