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Drug Name: compound tablet
English: Dispersible Compound Sulfamethoxazole Tablets
Pinyin:
main components: the goods is the main component of sulfamethoxazole and trimethoprim
traits: the goods the white tablets.
pharmacological effects: 1. Compound sulfamethoxazole can warfarin (warfarin) the role of anticoagulation by
strong, it should monitor the prothrombin time.
2. Goods from the plasma protein binding site replacement of certain drugs: Commodities make oral hypoglycemic drugs
reducing blood glucose increased role: to increase the effect of bone marrow methotrexate; The half-life extension of phenytoin.
3. Some drugs, such as acid-Son, dicoumarol and salicylic acid from the plasma protein binding sites a replacement
sulfamethoxazole.
4. Sulfa drugs and Thiazide diuretics at the same time applications more easily thrombocytopenia.
Pharmacokinetics: sulfamethoxazole (SMZ) completely absorbed after oral administration (about 90%), after administration
3.4 ± 0.8 hours of peak plasma concentration. After absorbing widely distributed in the body and body fluids
easily penetrate the blood-brain barrier and the placental barrier. For 0.36L/kg apparent volume of distribution, protein binding rate is 60 ~ 80%, about half bad
of 8.81 ± 1.85 hours. The goods mainly in the liver metabolism without the antibacterial activity of acetylation, but still SD
toxicity. Liver dysfunction, decreased metabolism. After administration of the goods within 24 hours about 16 ~ 32% of the original
shaped by the urine from about 30% in the form of emission of acetylcholine.
trimethoprim (TMP) after oral absorption completely (about 90%) and 1.50 ± 0.81 after administration
hour blood concentration of the peak. After absorbing widely distributed to organizations and body fluids, cut through the blood-brain barrier and the placental barrier.
apparent volume of distribution for the 1.2 ~ 2.2l/kg, protein binding rate is 30 ~ 46%, half-life of 9.16 ± 1.66 hours (without
urine at 20 ~ 50 hours). The 24 hours after administration for about 40 ~ 60% excreted, 80 ~ 90%
from a prototype drug, and the remaining part to the form of metabolites from.
indications: apply to the goods-sensitive Escherichia coli, Klebsiella pneumoniae isolates, Proteus
distance of urinary tract infection caused by the treatment. Also for the treatment of the following diseases; Haemophilus influenza or pneumococcal
of children with acute otitis media; Haemophilus influenza or pneumococcal cause of adult acute chronic bronchitis for the
, Freund's Song and the magnitude of bacterial dysentery caused by Shigella; Pneumocystis carinii infection.
usage and consumption: with warm water dispersed after oral administration may also obtain the entire film.
common in adults: the treatment of bacterial infections, a two oral, once every 12 hours.
flu treatment with parasites such as Pneumocystis carinii pneumonia, one two, one every six hours.
infants born less than in January using this ban.
adverse reaction: 1. Anaphylaxis is more common: drug eruption may be in serious can happen exudative
erythema multiforme, exfoliative dermatitis and epidermolysis bullosa atrophic dermatitis; Also for the performance by
-light sensitivity, drug fever, joint and muscle pain, fever-like disease, serum response.
2. Can cause of neutropenia, leukopenia, thrombocytopenia disease and aplastic anemia: Patients with angina may occur
, fever, pale and bleeding tendency, in the body of sulfa drugs should be regularly checked as peripheral blood, hair is abnormal
timely withdrawal.
3. Can cause hemolytic anemia and Hemoglobinuria: lack of glucose -6 - phosphate dehydrogenase patients with sulfa drugs
prone in newborns and adults than in children seen.
4. Can cause of neonatal hyperbilirubinemia and Kernicterus: As the sulfa drug and bilirubin
competitive protein binding site, free of bilirubin can be increased; Neonatal liver function is imperfect, poor handling of bilirubin, it vulnerable
hyperbilirubinemia and neonatal jaundice, can occur even nuclear jaundice.
5. Can cause liver damage: in jaundice, liver dysfunction, severe acute liver necrosis can occur.
6. May cause kidney damage: a crystallization of urine, hematuria and urinary tube, as long should be using this treatment, the dose
timely service with sodium bicarbonate and water to prevent kidney damage; The treatment of at least 2 to 3 times a week urine
routine inspection, if found to be crystal urine or hematuria to drink a lot of water and sodium bicarbonate until crystallization eliminate
hematuria and urinary loss; water loss, shock and elderly patients should be using this prone to cause kidney damage.
7. There will be nausea, vomiting, decreased counters, diarrhea, headaches, fatigue, general mild symptoms, not
effects continue medication.
8. Occasionally goiter and hypothyroidism.
of taboos: right sulfa drug allergies, and pregnant women prohibited.
Note: 1. Cross-allergic reaction: a sulfa drug to other patients were allergic to sulfa drug allergies can
.
2. Right furosemide, Sulfones, Thiazide diuretics, sulfonylurea, carbonic anhydrase inhibitor showed
suffering from allergy, the sulfa drug allergies can be.
3. Sulfa drugs can cross the placenta barrier, in fetal blood and bilirubin competitive binding sites, resulting free-red bile
increased, in hyperbilirubinemia and nuclear jaundice may therefore not using this late pregnancy.
4. Sulfa drugs can be secreted in the milk, milk concentrations up to maternal plasma concentration of 50 to 100%,
drugs may have an impact on the infant. Sulfa drugs in the glucose -6 - phosphate dehydrogenase deficiency in the newborn lead to the application
hemolytic anemia may occur. In light of the above reasons, breast-feeding women should not be using this.
5. The sulfa drug can cause hemolytic nuclear neonatal jaundice and other side effects of the goods is not appropriate for newborns
systemic administration.
6. Renal failure patients, such as creatinine clearance rate >30ml/min, would still be able to provide constant, creatinine clearance rate in the 15 ~
coefficients, constant halved, <15ml/min creatinine clearance rate, it is not appropriate to use.
7. Should anti following: lack of glucose -6 - phosphate dehydrogenase, liver dysfunction, hematoporphyrin of.
8. The attention to the treatment of inspection: (a) routine inspection of accepting a longer course of treatment of patients is particularly important;
(2) the treatment of regular urine routine inspection (every 2 to the 3rd time) to find a long course of treatment or high-dose treatment may occur crystallization
urine .
specifications: each containing 0.4 g sulfamethoxazole, trimethoprim 80mg.
Storage: shading confined preservation.
Validity: tentative 2003.
prescription drugs:
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