Drug Name: trimebutine maleate tablets
English: Trimebutine Maleate Tablets
main components: the main ingredients of goods Trimebutine
traits: $ white or white-Class .
pharmacological effects: 1. The role of the digestive tract
Movement (1) regulation of gastric motility
isolated guinea pig stomach muscle specimens vestibule of the ring 10-5g/ml accession to the drug can reduce the amplitude of the self-regulatory movement. In addition: the same can also increase the specimens in 28 ° Cweak anomalies in the frequency and amplitude of movement, it tends to the rhythm of contraction.
when to cut off the chest vagus nerve anesthetized dogs for the intravenous dose of the drug, it can stomach more irregular movement of the law.
to have digestive diseases of the gastric movement, 1mg / kg intravenous injection, can inhibit the movement found hyperparathyroidism muscle movement. Meanwhile, it is also found to increase the lower muscle movement function campaign.
(2) promote the digestive system of exercise-induced human jejunum
role within ~ 4 kg after treatment found that the digestive system can be induced by physiological adult gastrointestinal promote sports.
(3) improve the function of gastric emptying
have recurrent unexplained gastrointestinal discomfort in the abdomen of patients with chronic gastritis, oral 200mg of the drug, the weakening of gastric emptying can be improved, while the gastric emptying hyperthyroidism can be inhibited.
(4) regulation of intestinal movement
(5) of guinea pig colon specimens in vitro experiments, in 10-5g/ml, muscle tension in the lower right (low load), increased tension in the role of the muscle tension of hyperthyroidism (high load), a lower tensions and reduce the role of the amplitude.
right allergic colitis syndrome caused by psychological exhaustion load colorectal campaign hyperthyroidism, taking 300mg of the goods can be inhibited.
Slovakia for the new load-induced movement in patients with hyperthyroidism, 50 mg intravenous injection inhibited ileum, ascending colon, colon S-shaped movement to the load level before.
(6) including about esophageal pressure (LESP)
role in the regulation of narcotic dogs esophageal pressure experiments show that about include: HR intravenous dosage can reduce the four peptides promote gastrin load caused by internal pressure, but also can promote intestinal juice-induced pressure drop within the low been up.
(7) of the gastrointestinal smooth muscle
direct role in the vestibule of isolated guinea pig stomach muscle specimens of the experimental ring, found that even in the atropine and phentolamine, propranolol, and the existence of puffer poisoning, the drugs are still on the direct role of gastrointestinal smooth muscle.
right of isolated guinea pig ileum was found that liver because of a non-competitive inhibition of acetylcholine caused by contraction. Also found and anesthetized dogs with chest vagus nerve, digestive movement still direct role.
2. Town spit peripheral role
right dog was found that although the apomorphine-induced vomiting inhibit its weaker, but because of the copper sulfate-induced vomiting, intravenous or oral 60mg/kg dose, can significantly prolong the time required to induce vomiting.
Pharmacokinetics: 300mg oral the goods after peak hours and peak concentrations were 0.63 ± 0.24 and 312.01 ± 119.72ng/ml hours, the average residence time (MRT) and T1 / 2 were 2.58 ± 0.81 and 1.82 ± 0.43 hours hours. Hydrolysis of the goods in vivo, forming N-demethylation of the metabolism, from the urine.
indications: (a) Gastrointestinal motility disorder caused by loss of appetite, nausea, vomiting, vegetables, abdominal distention, abdominal Wong, abdominal pain, diarrhea, constipation and other symptoms improved.
(2) Intestinal irritability syndrome.
usage and consumption: adult oral, each 0.1 to 0.2 g three times a day, according to age, symptoms appropriate dose changes, or compliance.
adverse reaction: sometimes feel thirsty, numbness in the mouth, abdominal Wong, constipation, and tachycardia, drowsiness, dizziness, headache, rash, GOT, GPT increased, the incidence is about 0.4% .
of taboos: right allergic to the goods prohibited.
Note: 1. Pregnant women, breastfeeding women, anti-children.
2. Patients should be a rash of withdrawal.
Storage: sealed and kept in cool dry place.
Validity: tentative two years.
Warning:The information is only as a reference for new drug researcher and the patients or doctors can't use it as prescription basis!
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