| Original document(62 pages) Authorized document(54 pages) 中文版 |
A heterocyclic oxophthalazinyl acetic acid having aldose reductase inhibitory activity has the formula wherein X is oxygen or sulfur, Z is a covalent bond, O, S, NH or CH2; R1 is hydroxy, or a prodrug group; R2 is a heterocyclic group, R3 and R4 are hydrogen or the same or a different substituent, and R5 is hydrogen or methyl. The pharmaceutically acceptable acid addition salts of the above compounds and the pharmaceutically active base addition salts of the above compounds are also aldose reductase inhibitors. |
Application Number
申请号 |
86108308 |
Application Date
申请日 |
1986.11.06 |
| Title 名称 |
Process for preparing heterocycle-oxo-2,3-diazanaphthyl-acetic acid |
Publication Number
公开号 |
1012072 |
Publication Date
公开日 |
1987.07.15 |
| Approval Pub. Date |
1991.06.19 |
Granted Pub. Date |
1991.06.19 |
| International Classification 分类号 |
C07D403/06;C07D403/12;C07D403/14;C07D405/06;C07D405/12;C07D405/14;C07D409/06;C07D409/12;C07D409/14;C07D413/06;C07D413/12;C07D413/14;C07D417/06;C07D417/12;C07D417/14 |
Applicant(s) Name
申请人 |
Pfizer Inc. |
| Address 地址 |
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| Inventor(s) Name 发明人 |
Alik Robert Lason;Barawara Rakshmara Mirali |
| Attorney & Agent 代理人 |
LUO CAIXI |
| More information 更 多 信 息 |
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