| Original document(57 pages) 中文版 |
Quinone derivatives represented by the general formula (I) (wherein, R1 and R2, the same or different, refer to hydrogen atom, methyl or methoxymethyl group, or R1 and R2 bind together to form -CH=CH-CH=CH-; R3 is hydrogen atom or methyl group; R4 is nitrogen-containing heterocyclic group which may be substituted; R5 is hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or carboxyl group which may be esterified or amidated; Z is (wherein, R' is hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropriately in the repeating unit shown in []), and the hydroquinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of poly unsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabolites in 5-lipoxygenase pathway, inhibition of thromboxane A2 synthetase, thromboxane A2 receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therpeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc. |
Application Number
申请号 |
87100723 |
Application Date
申请日 |
1987.01.30 |
| Title 名称 |
Quinone derivatives, their production and use |
Publication Number
公开号 |
1013275 |
Publication Date
公开日 |
1987.09.16 |
| Approval Pub. Date |
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Granted Pub. Date |
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| International Classification 分类号 |
A61K31/44;C07D213/30;C07D227/04;C07D409/06 |
Applicant(s) Name
申请人 |
Takeda Chemical Industries, Ltd. (JP) 27, Doshomachi 2-Chome, Higashi-Ku, Osaka |
| Address 地址 |
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| Inventor(s) Name 发明人 |
Kohei Nishikawa;Shinji Terao |
| Attorney & Agent 代理人 |
LUO HONG |
| More information 更 多 信 息 |
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