| Original document(20 pages) Authorized document(21 pages) 中文版 |
The invention relates to a new and improved process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(N,N-dimethyl-acetamide) of Formula (I) and pharmaceutically acceptable acid addition salts thereof which comprises reacting an ester of general Formula (II) (wherein R is lower alkyl or phenyl-lower alkyl) in a polar protic or aprotic solvent with dimethyl amine and, if desired, converting the compound of the Formula (I) thus obtained into a pharmaceutically acceptable acid addition salt. The compound of Formula I is a known valuable sedative used in therapy. The invention also relates to new intermediates of general Formula (II) (wherein R is lower alkyl or phenyl-lower alkyl) useful in the process. |
Application Number
申请号 |
00817304 |
Application Date
申请日 |
2000.11.22 |
| Title 名称 |
Process for preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo [1,2-a] pyrimidine-3-(N,N-dimethyl-acetamide) and intermediates |
Publication Number
公开号 |
1413212 |
Publication Date
公开日 |
2003.04.23 |
| Approval Pub. Date |
2005.11.16 |
Granted Pub. Date |
2005.11.16 |
| International Classification 分类号 |
C07D471/04 |
Applicant(s) Name
申请人 |
Egis Gyogyszergyar RT |
| Address 地址 |
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| Inventor(s) Name 发明人 |
L. Pong;J. P. Simig |
| Attorney & Agent 代理人 |
li huayang |
| More information 更 多 信 息 |
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