The present invention provides recombinant yellow fever viruses, particularly live attenuated recombinant, which comprise exogenous nucleotide sequences which encode exogenous amino acid sequences. These recombinant yellow fever viruses comprise an exogenous nucleic acid. Infection of a host cell with a recombinant yellow fever provides for expression of the exogenous nucleic acid in a host cell and production of an antigenic polypeptide encoded by the exogenous nucleic acid. Such recombinant yellow fever are useful in eliciting an immune response to the exogenous polypeptide. |