| Original document(12 pages) 中文版 |
In the present invention, the biological TIMP-4 gene medicine contains complete cDNA sequence of TIMP-4 gene and the gene of PCINTIMP-4 vector, and TIMP-4 gene is assembled into specific expressing vector PcI-neo of mammal cell to subclone PCINTIMP-4. TIMP-4 gene protein has the powerful functions of inhibiting MMP enzyme, inhibit cell migration of smooth muscles, reducing the change of smooth muscle cell to become spindle cell and inhibiting the proliferation of connective fiber tissue in blood vessel cavity, so that it can inhibit abnormal repair course in blood vessel cavity for normal endothelium repair. The present invention has important application especially in preparing medicine for preventing blood vessel from becoming narrow again. |
Application Number
申请号 |
02104301 |
Application Date
申请日 |
2002.02.19 |
| Title 名称 |
Application of TIMP-4 gene in preparing medicine for treating cardiac vascular disease and repairing scar clinically |
Publication Number
公开号 |
1398639 |
Publication Date
公开日 |
2003.02.26 |
| Approval Pub. Date |
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Granted Pub. Date |
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| International Classification 分类号 |
A61K48/00,A61P43/00 |
Applicant(s) Name
申请人 |
Wang Mingsheng |
| Address 地址 |
100086 |
| Inventor(s) Name 发明人 |
Wang Mingsheng |
| Attorney & Agent 代理人 |
gao cunxiu |
| More information 更 多 信 息 |
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