| Original document(11 pages) 中文版 |
The biodegradable microcapsulated ultrasonic contrast medium is a hollow microcapsule with size of 1-10 microns and wall thickness of 50-6000 nm. The preparation process includes the steps of: dissolving biodegradable fatty polylactone with organic solvent to compound solution A; adding emulsifier into distilled water to compound solution B; injecting solution B into solution A via supersonic emulsifying; adding the emulsion into water solution of stabilizer via stirring; stirring for 2-10 hr to separate microcapsules particle and washing with distilled water; and freeze drying the particle to obtain powdered biodegradable microcapsule. Via intravenous injection or intravenous dripping, the present invention may be made to enter myocardial microcirculation via left cardiac chamber and coronary artery for supersonic radiographic examination. |
Application Number
申请号 |
02132252 |
Application Date
申请日 |
2002.09.03 |
| Title 名称 |
Biodegradable microcapsulated ultrasonic contrast medium and its prepn process |
Publication Number
公开号 |
1398640 |
Publication Date
公开日 |
2003.02.26 |
| Approval Pub. Date |
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Granted Pub. Date |
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| International Classification 分类号 |
A61K49/06,A61K49/18 |
Applicant(s) Name
申请人 |
Inst. of Chemistry, Chinese Academy of Sciences |
| Address 地址 |
100080 |
| Inventor(s) Name 发明人 |
Wang Shenguo, Zhi Guang |
| Attorney & Agent 代理人 |
zhou changxin |
| More information 更 多 信 息 |
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