Propellant-free spray-on skin patch composition comprising at least one substantially water insoluble film forming agent, at least one film plasticiser agent, at least one water soluble compound, at least one organic solvent and optionally a physiologically active ingredient or pro-drug thereof. The composition forms a flexible, porous and physiologically compatible skin patch when sprayed onto skin and allowed to dry. Also described are methods of improving wound healing using the above composition to form a protective film over the wound, and a spray patch transdermal drug delivery system for delivering to or through the skin a physiologically active ingredient or a prodrug thereof. |