| Original document(158 pages) Authorized document(158 pages) 中文版 |
The invention relates to compounds for treating pathological conditions or diseases wherein one (or several) somatostatin receptors is (are) involved, corresponding to general formula (I) wherein: R1 represents in particular a carbocyclic or heterocyclic aryl radical optionally substituted or a non-aromatic heterocyclic radical optionally substituted; R2 represents H, alkyl or aryl optionally substituted; R3 represents H or -(CH2)p-Z3, Z3 representing in particular alkyl, cycloalkyl, bis-arylalkyl or di-aryalkyl, -Y1-(CH2)p-phenyl-(X1)n, carbocyclic or heterocyclic aryl optionally substituted, a non-aromatic heterocyclic radical optionally substituted, X1, every time it is present, being independently selected in particular among the radicals H, Cl, F, Br, I, CF3, NO2, OH, NH2, CN, N3, -OCF3, alkyl, alkoxy, -S-alkyl, -(CH2)p-NH2, -(CH2)p-NH-alkyl, -(CH2)p-N-dialkyl; Y1 represents O, S, NH or is not present; R4 represents -(CH2)p-Z4, Z4 representing in particular amino, alkylamino, N,N-dialkylamino; R5 represents in particular H or alkyl; X represents O or S; p each time it is present is independently 0 or an integer ranging between 1 and 6; q each time it is present is independently an integer between 1 and 5; n represents 0 or 1; provided that when n represents 0, m represents 1, 2 or 3, and when n represents 1, m represents 0 or 1. |
Application Number
申请号 |
00811065 |
Application Date
申请日 |
2000.07.28 |
| Title 名称 |
Novel hydantoin, thiohydantoin, pyrimidinedione and thioxopyrimidinone derivatives, preparation method and use as medicines |
Publication Number
公开号 |
1399631 |
Publication Date
公开日 |
2003.02.26 |
| Approval Pub. Date |
2004.12.01 |
Granted Pub. Date |
2004.12.01 |
| International Classification 分类号 |
A61K31/415;A61K31/505;A61P5/02;C07D233/78;C07D233/86;C07D403/04;C07D403/06;C07D403/14;C07D405/14;C07D407/14;C07D409/14;C07D413/14;C07D417/14 |
Applicant(s) Name
申请人 |
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) |
| Address 地址 |
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| Inventor(s) Name 发明人 |
Lydie Poitout;Christophe Thurieau;Valelie Brault |
| Attorney & Agent 代理人 |
liu jinhui huang gesheng |
| More information 更 多 信 息 |
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