| Original document(155 pages) 中文版 |
This invention relates to novel lactams having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A beta -peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta -amyloid production such as Alzheimer's disease and Down's Syndrome. |
Application Number
申请号 |
00812784 |
Application Date
申请日 |
2000.09.13 |
| Title 名称 |
Hydroxyalkanoyl aminolactams and related structure as inhibitors of A beta protein production |
Publication Number
公开号 |
1399634 |
Publication Date
公开日 |
2003.02.26 |
| Approval Pub. Date |
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Granted Pub. Date |
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| International Classification 分类号 |
A61K31/55;A61P43/00;C07D223/12;C07D243/24;C07D401/04;C07D401/06;C07D403/12;C07D405/12;C07D409/12 |
Applicant(s) Name
申请人 |
Bristol-Myers Squibb Pharma, Inc. |
| Address 地址 |
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| Inventor(s) Name 发明人 |
R.E. Olson;H. Liu;L.A. Thompson III |
| Attorney & Agent 代理人 |
zhang yuanzhong yang jiuchang |
| More information 更 多 信 息 |
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