| Original document(27 pages) 中文版 |
The invention is directed to tricyclic indoloazepine compounds useful as vasopressin receptor antagonists, pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions involving increased vascular resistance and cardiac insufficiency which include hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, Cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis or water retention in a subject in need thereof. |
Application Number
申请号 |
00811602 |
Application Date
申请日 |
2000.06.15 |
| Title 名称 |
Indoloazepines as vasopressin receptor antagonists |
Publication Number
公开号 |
1399638 |
Publication Date
公开日 |
2003.02.26 |
| Approval Pub. Date |
|
Granted Pub. Date |
|
| International Classification 分类号 |
A61K31/55;A61P9/12;C07D487/06 |
Applicant(s) Name
申请人 |
Ortho-McNeil Pharmaceutical, Inc. |
| Address 地址 |
|
| Inventor(s) Name 发明人 |
W.J. Hoekstra;M.N. Greco;L.R. Hecker |
| Attorney & Agent 代理人 |
zhang yuanzhong zhong shouqi |
| More information 更 多 信 息 |
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