The preparation process of oral Nimoldipine preparation includes the technological steps of: adding polymer carrier hydroxyproply methyl cellulose, polysorbate-80, absorption promoter sodium dodecyl sulfate into ethanol; heating to become transparent; adding low smelting point Nimoldipine while stirring until becoming transparent; quick freezing at -35 to -25 deg.c; adding absorption promoter oleic acid, avical and carboxy methyl amylose sodium to prepare soft material; pelletizing with 18-mesh nylon sieve; drying at 40-50 deg.c; finishing and capsulizing. The Nimoldpine capsule has biological utilization of 94.82% of that of Nimoldipine. |