| Original document(55 pages) Authorized document(46 pages) 中文版 |
Homogeneous and multiplex assays for target nucleic acids hybridized to oligonucleotide probes immobilized on particulate and non-particulate substrates are described. Target nucleic acids are determined using detection methods, such as flow cytometric methods, capable of particle discrimination based on the light scattering or fluorescence properties of the particle, or by spatial resolution of oligonucleotides immobilized at specific loci on a substrate. Target-correlated fluorescence signal, originating from a target nucleic acid hybridized to the substrate-immobilized oligonucleotide is determined as a measure of the presence or amount of the target nucleic acid. |
Application Number
申请号 |
00818981 |
Application Date
申请日 |
2000.12.21 |
| Title 名称 |
Detection of nucleic acids |
Publication Number
公开号 |
1434874 |
Publication Date
公开日 |
2003.08.06 |
| Approval Pub. Date |
2007.04.25 |
Granted Pub. Date |
2007.04.25 |
| International Classification 分类号 |
C12Q1/68;C07H21/04;G01N31/22;C12M1/36 |
Applicant(s) Name
申请人 |
Ortho-Clinical Diagnostics, Inc. |
| Address 地址 |
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| Inventor(s) Name 发明人 |
M.C. Connelly;G. Serino;T.J. Mercolino |
| Attorney & Agent 代理人 |
xu yanyi |
| More information 更 多 信 息 |
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