Original document(6 pages) Authorized document(7 pages) 中文版
    The preparation method of aspirin microsphere adopts oil-in-oil technique, its internal oil phase is an organic solution of polycaprolactone, polylactic acid or polylactic acid copolymer, and the liquid paraffin or vegetable oil is its external oil phase, and its emulsifier is Span. When it is prepared, the clathate of the cyclodextrin or cyclodextrin derivative of aspirin can be dispersed in internal oil phase by using ultrasonic wave, then the internal oil phase is emulsified in external oil phase by means of medium-speed stirring, and then the internal oil phase solvent is volatilized at 20-50 deg.c, after the microspheres are handened, they are undergone the processes of centrifugal separation, washing with petroleum ether and natural drying at room temp. so as to obtain the invented product.
Application Number
03129097 Application Date
Title 名称 Preparation method of aspirin microsphere
Publication Number
1460469 Publication Date
Approval Pub. Date Granted Pub. Date 2006.01.25
International Classification 分类号 A61K9/50,A61K47/40,A61K31/60
Applicant(s) Name
Zhejiang Univ.
Address 地址 310027
Inventor(s) Name 发明人 Zhu Kangjie
Attorney & Agent 代理人 zhang fagao

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