| Original document(17 pages) 中文版 |
The present invention relates to new compound diethyl 4-(4-oxobutyl) benzoyl-L-glutamate and its preparation process and application. The compound diethyl 4-(4-oxobutyl) benzoyl-L-glutamate in the chemical expression as shown is prepared through the reaction of compound diethyl 4-bromo benzoyl-L-glutamate and 3-butene-1-alcohol inside NN-dimethyl formamide solvent under the action of palladium acetate catalyst, weak alkali reagent, lithium halide and phase transfer catalyst in the protection of inert gas at 50-70 deg.c. The compound diethyl 4-(4-oxobutyl) benzoyl-L-glutamate is used in synthesizing diethyl 4-[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate as the intermediate of Pemetrexed disodium. The present invention results in shortened Pemetrexed disodium synthesizing path and lowered production cost. |
Application Number
申请号 |
200610050092 |
Application Date
申请日 |
2006.03.29 |
| Title 名称 |
Diethyl 4(4-oxobutyl) benzoyl-L-glutamate and its preparation and use |
Publication Number
公开号 |
1821219 |
Publication Date
公开日 |
2006.08.23 |
| Approval Pub. Date |
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Granted Pub. Date |
|
| International Classification 分类号 |
C07C235/84,C07C231/12 |
Applicant(s) Name
申请人 |
Zhejiang Polytechnic Univ. |
| Address 地址 |
310014 |
| Inventor(s) Name 发明人 |
Su Weike, Li Zhenhua, Wang Ping |
| Attorney & Agent 代理人 |
huang meijuan yuan muji |
| More information 更 多 信 息 |
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