The invention discloses a method for preparation of inner- type nano pore silica sorbent used for separating and purifying medicine, belonging to the technique of synthesizing sorbent. The technique contains the following steps: dissolving medicine compound into solvent containing chloroform to prepare a solution, mixing the solution with organosilane with a molar ratio of medicine compound to organosilane, mixing around, and then removing the solvent to prepare predecessor material. Dissolving tetraethoxysilane into ethanol solution, adding the predecessor material, hydrolyzing, and gelling and aging to prepare xerogel. Grinding the xerogel and stripping medicine compound with chloroform- contained eluent to prepare built-in type nano pore silica sorbent. For molecular engram and identification of the material proceed in polar solvent, it can be used to separate and purify water-soluble medicine component. Adsorbance of the sorbent can reach up to 6mg/ g, and the selectivity ratio of absorption can reach up to 80%. |