| Original document(59 pages) 中文版 |
There are disclosed novel compounds of formula (I) wherein A, R<1>, R<2>, R<3> and X are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, atherosclerosis and pain. |
Application Number
申请号 |
200480027529 |
Application Date
申请日 |
2004.10.05 |
| Title 名称 |
New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1 |
Publication Number
公开号 |
1856499 |
Publication Date
公开日 |
2006.11.01 |
| Approval Pub. Date |
|
Granted Pub. Date |
|
| International Classification 分类号 |
C07D513/04,C07D475/06,A61K31/519,A61P25/28,A61P9/10 |
Applicant(s) Name
申请人 |
Astrazeneca AB |
| Address 地址 |
|
| Inventor(s) Name 发明人 |
Sohn Daniel D., Nordvall Gunnar, Rein Tobias |
| Attorney & Agent 代理人 |
zhang bengyuan zhao renlin |
| More information 更 多 信 息 |
|
| Related patents information |
|
|
|
|
|
|