| Original document(79 pages) Authorized document(80 pages) 中文版 |
Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A alpha , B beta and gamma chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed. |
Application Number
申请号 |
95191945 |
Application Date
申请日 |
1995.03.01 |
| Title 名称 |
Production of fibrinogen in transgenic animals |
Publication Number
公开号 |
1144539 |
Publication Date
公开日 |
1997.03.05 |
| Approval Pub. Date |
2002.02.20 |
Granted Pub. Date |
2002.02.20 |
| International Classification 分类号 |
A01K67/027;C07K14/75;C12N15/62;C12N15/63;C12N15/85;C12N15/89;C12N15/90 |
Applicant(s) Name
申请人 |
Zymogenetics, Inc. |
| Address 地址 |
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| Inventor(s) Name 发明人 |
Ian Garner;Michael A. Dalrymple;Donna E. Prunkard |
| Attorney & Agent 代理人 |
LIU GUOPING |
| More information 更 多 信 息 |
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