A sense amplifier, including a first stage amplifier and a second stage amplifier, for compensating input offset voltage changes due to temperature variation of the sense amplifier. The first stage amplifier receives a data voltage and a reference voltage, and outputs a first data output and a second data output. The first stage amplifier receives an adjusted voltage, and is biased at an internal voltage. The second stage amplifier includes a latch, for level-shifting and amplifying the first and second data output, and is biased at an external voltage. The sense amplifier further includes a bias circuit, for generating the adjusted voltage according to temperature variation of the sense amplifier, to reduce the input offset voltage changes. |