Original document(32 pages)  中文版
    Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-1,2,4-triazole are potent inhibitors of 11beta-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment.
Application Number
申请号
200580003124 Application Date
申请日
2005.01.21
Title 名称 Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1
Publication Number
公开号
1910161 Publication Date
公开日
2007.02.07
Approval Pub. Date Granted Pub. Date
International Classification 分类号 C07D249/08;A61K31/4196
Applicant(s) Name
申请人
Merck & Co. Inc.
Address 地址
Inventor(s) Name 发明人 Bereznitski Yuri;Huffman Mark A.;Lynch Joseph E.;Zhao Matthew
Attorney & Agent 代理人 wang yingyu li liantao
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