Original document(61 pages)  中文版
    The invention relates to a compound having general formula (I), wherein: R1 represents either an optionally-substituted C1-6 alkyl or a C3-7 cycloalkyl, a thiophene, a benzothiophene, a pyridinyl, a furanyl or a phenyl, said phenyl groups being optionally substituted; R2 and R'2 represent, independently of each other, a hydrogen atom, a halogen atom, a hydroxy, a C1-3 alkoxy, a C1-3 alkyl, a C3-7 cycloalkyl, an O-C(O)-C1-6 alkyl group, or R2 and R'2 together form an oxo group; R3 represents either a hydrogen atom or an optionally-substituted C1-6 alkyl; R4 and R5 represent, independently of each other, a hydrogen atom, a C1-7 alkyl, a trifluoromethyl, an L group or a Z group; G represents a C1-7 alkyl or a single bond; M represents a C3-7 cycloalkyl, a phenyl, a naphtyl or a pyridinyl, group M being optionally substituted; J represents a hydrogen atom or a group -Y-K; Y represents a single bond, an oxygen atom, a sulphur atom, an optionally-substituted -C1-4 alkylene- group, -O-C1-4 alkylene-, -C1-4 alkylene-O- or -N(W)-; K represents a phenyl or pyridinyl group, group K being optionally substituted, with the proviso that at least one R4 or R5 group represents a Z group; and Z represents a group CN, SO2NR6R7, or a heteroaromatic group, said heteroaromatic group being optionally substituted. The inventive compound takes the form of a base, an acid addition salt, a hydrate or a solvate.
Application Number
申请号
200580002588 Application Date
申请日
2005.01.07
Title 名称 Acylaminothiazole derivatives and use thereof as beta-amyloid inhibitors
Publication Number
公开号
1910165 Publication Date
公开日
2007.02.07
Approval Pub. Date Granted Pub. Date
International Classification 分类号 C07D277/36;C07D277/56;C07D417/04;C07D417/12;A61K31/426;A61K31/427;A61P25/28
Applicant(s) Name
申请人
Sanofi Aventis
Address 地址
Inventor(s) Name 发明人 Baltzer Sylvie;Pascal Marc;Van Dorsselaer Viviane
Attorney & Agent 代理人 liu weisheng lin sen
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