| Original document(42 pages) 中文版 |
The invention relates to a compound having general formula (I), wherein: m represents an integer equal to 1 or 2; R1 represents an aryl- or heteroaryl-type group that is optionally substituted by one or more R3 or R4 groups; R2 represents a group having general formula CHR5CONHR6; R3 represents a halogen atom or a hydroxy, cyano, nitro, C1-6-alkyl, C1-6-alkoxy, C1-6-thioalkyl, C1-6-fluoroalkyl, C1-6-fluoroalkoxy, -O-(C2-3-alkylene)-, -O-(C1-3-alkylene)-O-, C1-6-fluorothioalkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkylene, piperidinyl, benzyloxy, piperazinyl, pyrrolidinyl, morpholinyl, phenyloxy, NR7R8, NHCOR7, NHSO2R7, COR7, C02R7, CONR7R8, SO2R7 or SO2NR7R8 group; R4 represents an aryl- or heteroaryl-type group, whereby the R4 group(s) can be substituted by one or more identical or different R3 groups; R5 represents a hydrogen atom or a C1-3-alkyl group; R6 represents a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-3-alkylene group; and R7 and R8 represent, independently of each other, a hydrogen atom, a C1-3-alkyl group or a phenyl group, said compound taking the form of a base, an acid addition salt, a hydrate or a solvate. The invention also relates to the use of the compound in therapeutics. |
Application Number
申请号 |
200480040912 |
Application Date
申请日 |
2004.12.17 |
| Title 名称 |
Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same in therapeutics |
Publication Number
公开号 |
1922161 |
Publication Date
公开日 |
2007.02.28 |
| Approval Pub. Date |
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Granted Pub. Date |
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| International Classification 分类号 |
C07D295/185;C07D311/04;C07D317/58;C07D307/81;C07D495/04;A61K31/495;A61K31/496;A61K31/55;C07C235/06;A61P29/00;A61P25/00;A61P35/00;A61P37/00;A61P31/00;A61P33/00 |
Applicant(s) Name
申请人 |
Sanofi Aventis |
| Address 地址 |
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| Inventor(s) Name 发明人 |
Abouabdellah Ahmed;Almario Garcia Antonio;Hoornaert Christian;Li Adrien Tak |
| Attorney & Agent 代理人 |
liu weisheng lin sen |
| More information 更 多 信 息 |
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