Original document(21 pages)  中文版
    Provided is an industrially applicable process for producing 1,2-cis-2-fluorocyclopropane-1-carboxylic ester. A process for producing a compound represented by formula (3): [wherein R 1 represents, for example, a C1-C8 alkyl group], which process includes reacting a compound represented by formula (1) : [wherein X 1 represents a hydrogen atom, a chlorine atom, a bromine atom, or an iodine atom; X 2 represents a hydrogen atom, a chlorine atom, a bromine atom, or an iodine atom; X 1 and X 2 are not simultaneously hydrogen atoms; and R 1 has the same meaning as defined in formula (3)] with a reducing agent represented by formula (2): [wherein M 1 represents an alkali metal atom; M 2 represents an alkaline earth metal atom or a zinc atom; R 2 represents, for example, a hydrogen atom; m represents an integer from 1 to 4; n represents an integer from 0 to 3; and the sum of m and n is 4] in the presence of an aprotic polar solvent, and a Lewis acid such as a halide of an atom selected from among, for example, boron, magnesium, and aluminum.
Application Number
申请号
200580006975 Application Date
申请日
2005.03.31
Title 名称 Process for producing 1,2-cis-2-fluorocyclopropane-1carboxylic ester compound
Publication Number
公开号
1930112 Publication Date
公开日
2007.03.14
Approval Pub. Date Granted Pub. Date
International Classification 分类号 C07C67/317;C07C69/74;C07B61/00
Applicant(s) Name
申请人
Daiichi Seiyaku Co.
Address 地址
Inventor(s) Name 发明人
Attorney & Agent 代理人 baoyu dun
More information 更  多  信  息


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