Original document(127 pages)  中文版
    The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes (Formula (I)). The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
Application Number
申请号		 200580007466 Application Date
申请日		 2005.03.07
Title 名称 MTP inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles
Publication Number
公开号		 1930143 Publication Date
公开日		 2007.03.14
Approval Pub. Date Granted Pub. Date
International Classification 分类号 C07D401/04;C07D417/10;C07D403/10;C07D401/10;C07D413/12;C07D249/08;C07D233/54;A61P19/00
Applicant(s) Name
申请人		 Janssen Pharmaceutica NV
Address 地址
Inventor(s) Name 发明人
Attorney & Agent 代理人 machong de liuyue
More information 更  多  信  息


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