A cycloalkanopyridine derivative represented by the general formula [I] wherein A1 to A4 each independently represents -C(R5)- or -N-, provided that at least one of A1 to A4 represents -N-; A5 to A8 each independently represents -C(R6)- or -N-; X represents -CH2-, -CH(OH)-, -N(Ra)-, -O-, -S-, or -SO2-; Y represents -CH2- or -N(Ra)-; Z represents -(CR7)- or -N-; n is 0 or 1; and R1 to R4 each represents hydrogen or a group, etc. This compound functions as a nociceptin receptor antagonist. It is useful as, e.g., a drug for overcoming resistance to narcotic analgesics for diseases in which a nociceptin receptor participates. |