| Original document(36 pages) 中文版 |
The invention relates to a compound having general formula (I), wherein: R1 represents either an optionally-substituted C1-6 alkyl or a C3-7 cycloalkyl, a thiophene, a benzothiophene, a pyridinyl, a furanyl or a phenyl which is optionally substituted; R2 and R'2 represent, independently of each other, a hydrogen atom, a halogen atom, a hydroxy, a C1-3 alkoxy, a C1-3 alkyl, a C3-7 cycloalkyl, a O-C(O)-C1-6 alkyl group, or R2 and R'2 together form an oxo group; R3 represents a hydrogen atom, a C1-6 alkyl which is optionally substituted by a hydroxy, a C1-6 cycloalkyl or a C1-3 alkoxy; either R4 or R5 represents a group (Z) and either R4 or R5 represents a -C(X)R6 group; G represents a single bond or a -CH2- group; Y represents a single bond, an oxygen atom, a sulphur atom, an optionally-substituted C1-4 alkylene group or -N(W)-; A and B represent, independently of each other, a hydrogen atom, a halogen atom, a hydroxy group, C1-3 alkyl, C1-3 alkoxy, trifluoromethyl, trifluoromethoxy or -O-CHF2; X represents O or S; R6 represents an optionally-substituted C1-6 alkoxy group, hydroxy or -NR7R8; and R7 and R8 represent, independently of each other, either a hydrogen atom, an optionally-substituted C1-6 alkyl group, an optionally-substituted C3-7 cycloalkyl group, C1-6 alkoxy or phenyl which is optionally substituted, or R7 and R8, together with the nitrogen atom bearing same, form an aziridine, azetidine, pyrrolidine, piperidine, morpholine or benzopiperidine ring. The inventive compound takes the form of a base, an acid addition salt or a hydrate. The invention also relates to the use of said compound in therapeutics. |
Application Number
申请号 |
200580005095 |
Application Date
申请日 |
2005.01.07 |
| Title 名称 |
Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics |
Publication Number
公开号 |
1930155 |
Publication Date
公开日 |
2007.03.14 |
| Approval Pub. Date |
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Granted Pub. Date |
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| International Classification 分类号 |
C07D417/12;C07D277/46;C07D417/06;A61K31/427;A61K31/426 |
Applicant(s) Name
申请人 |
Sanofi Aventis |
| Address 地址 |
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| Inventor(s) Name 发明人 |
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| Attorney & Agent 代理人 |
liuwei sheng linsen |
| More information 更 多 信 息 |
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