| Original document(119 pages) 中文版 |
The invention provides compounds of the formula (1), in which R1 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-l-4C-alkyl or hydroxy-1-4Calkyl, R2 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3-7C-cycloalkyl.-1-4C-alkyl, 1-4C-alkoxycarbonyl, hydroxy-1-4C-alkyl, hydroxy-3-4-C-alkenyl, hydroxy-3-4C-alkinyl, halogen, 2-4C-alkenyl, 2-4Calkynyl, fluoro-1-4C-alkyl, cyanomethyl, hydroxy, 1-4C-alkoxy, amino, mono- or di-1-4Calkylamino, 1-4C-alkylcarbonylamino, 1-4C-alkoxycarbonylamino, 1-4C-alkoxy-1-4Calkoxycarbonylamino, carboxyl, mono- or di-1-4C-alkylamino-1-4C-alkyl, 1-4C-alkylcarbonyl, 24C-alkenylcarbonyl, 2-4C-alkinylcarbonyl or the radical -CO-NR21R22, R3 is 1-4C-alkylcarbonyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkoxy-l4C-alkyl, 1-4C-alkoxycarbonyl, fluoro-1-4C-alkoxy-1-4C-alkyl, cyano, the radical -CO-NR31R32, the radical -S0<SUB>2</SUB>-NR31 R32, the radical -CS-NR31 R32, the radical -C=N(OH)-NR1 R32 or the group Het. Arom is a R4-, R5-, R6- and R7-substituted mono- or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, indolyl, benzimidazolyl, furanyl (furyl), benzofuranyl (benzofuryl), thiophenyl (thienyl), benzothiophenyl (benzothienyl), thiazolyl, isoxazolyl, pyridinyl, pyrimidinyi, quinolinyl and isoquinolinyl. The compounds inhibit the secretion of gastric acid. |
Application Number
申请号 |
200580006989 |
Application Date
申请日 |
2005.03.16 |
| Title 名称 |
7H-8,9-dihydro-pyrano(2,3-C)imidazo(1,2A)pyridine derivatives and their use as gastric acid secretion inhibitors |
Publication Number
公开号 |
1930171 |
Publication Date
公开日 |
2007.03.14 |
| Approval Pub. Date |
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Granted Pub. Date |
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| International Classification 分类号 |
C07D491/14;A61K31/437;C07D311/00;C07D235/00;C07D221/00 |
Applicant(s) Name
申请人 |
Altana Pharma AG |
| Address 地址 |
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| Inventor(s) Name 发明人 |
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| Attorney & Agent 代理人 |
weixin hua lilian tao |
| More information 更 多 信 息 |
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