The present invention relates to nanometer antitumor medicine, and discloses nanometer NAMI-A particle and its preparation process and application. The nanometer NAMI-A particle contains Ru complex NAMI-A and basic material of chitosan or PLGA. The nanometer NAMI-A particle may be prepared through a double emulsifying process or an ionic gel process, and has simple preparation process, high stability and high repeatability. The nanometer NAMI-A particle with biodegradable chitosan or PLGA as basic material has high biocompatibility, high anticancer activity, no toxic side effect, regular spherical form and controllable medicine release. |