The masked berberine hydrochloride micro pill is coated berberine hydrochloride micro pill, and the berberine hydrochloride micro pill is prepared with berberine hydrochloride and supplementary material through an extruding and centrifugal pelletizing process, a centrifugal laminating process or a rolling process in a sugar coating pot. The supplementary material is selected from microcrystalline cellulose, starch, cane sugar and dextrin, and accounts for 15-90 % of the micro pill. The coating material includes filming material, plasticizer and antiagglomerant. The masked berberine hydrochloride micro pill may be further prepared into granule, dispersed tablet, dry suspension, bolus or other preparation forms. The present invention has the bitter of berberine hydrochloride masked and thus raised patient's compliance, and is especially suitable for infant and old persons with dysphagia. |