The present invention relates to one kind of orally taken control released trimetazidine medicine composition and its preparation process. The trimetazidine medicine composition consists of trimetazidine or its physiologically acceptable salt in effective dosage and pharmaceutically acceptable medicine excipient capable of reaching release controlling osmotic pump effect. The medicine excipient is one or several selected from osmotic pressure active matter, permeation assistant, diluent, colorant, lubricant, moistener or adhesive, filming material, pore creating agent, plasticizer and solvent. |