The present invention discloses one kind of medicine composition for treating depression and relevant diseases, and the medicine composition includes certain amount of venlafaxine or its medicinal salt or solvate, certain amount of sulpiride or its solvate, and one or several kinds of medicine carrier or excipient. The medicine composition has such amount of sulpiride and venlafaxine as to result in synergistic effect. The medicine composition is used in treating depression and relevant diseases, and has less untoward reaction. |