The nanometer miconazole nitrate emulsion medicine consists of surfactant, oil, miconazole nitrate and distilled water. Its preparation process includes the following steps: weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil phase for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly; adding dimethyl sulphoxide with dissolved miconazole nitrate into surfactant through stirring at 20-25 deg.c; adding distilled water slowly to form clear and flowing O/W type nanometer emulsion liquid. The nanometer miconazole nitrate emulsion has high skin permeability, no contamination to clothing, high dissolubility of miconazole nitrate, raised bioavailability of miconazole nitrate, delayed metabolism time and wide medicine market foreground. |