The present invention discloses oral disintegrated difenidol hydrochloride tablet prepared through freeze- drying process and its preparation process. The oral disintegrated difenidol hydrochloride tablet has difenidol hydrochloride as main medicine component, solid dispersing carrier, disintegrant, effervescent agent, taste masking agent, excipient, etc. and features the freeze- drying preparing process. It may be disintegrated in oral cavity into particles smaller than 250 microns within 30 sec without need of water, and is especially suitable for patient with dysphagia. It has fast leaching out and absorption, fast acting and high bioavailability. |