The present invention relates to the application of diosgenin in preparing medicine with synergistic attenuation on chemotherapeutic medicine, and belongs to the field of new use of diosgenin. Diosgenin has synergistic attenuation effect on chemotherapeutic medicine for human melanoma, cervical carcinoma, gastric carcinoma and mammary cancer, and may be used to cooperate with chemotherapeutic medicine so as to generate synergism and attenuation effects. The present invention can reduce the dosage of chemotherapeutic medicine and decrease the toxic side effect of chemotherapeutic medicine. |