Original document(48 pages)  中文版
    The invention provides a GMP compatible method to chemically synthesize proteins which may be advantageously used in compositions for vaccination that are free of biological contaminants. The method uses conventional synthesis of peptides and linking these to yield synthetic proteins that preferably comprise all T cell epitopes for an antigen. Preferably an adjuvant is covalently attached to a synthetic protein to yield a fully synthetic vaccine. The invention is illustrated mainly by using HPV proteins directed immunity as a model.
Application Number
申请号		 200380111053 Application Date
申请日		 2003.12.24
Title 名称 Synthetic protein as tumor-specific vaccine
Publication Number
公开号		 1950106 Publication Date
公开日		 2007.04.18
Approval Pub. Date Granted Pub. Date
International Classification 分类号 A61K39/00;C07K14/00;C07K14/025
Applicant(s) Name
申请人		 Leiden University Medical Center.
Address 地址
Inventor(s) Name 发明人 Van Der Burg Sjoerd Hendrikus;Drijfhout Jan Wouter
Attorney & Agent 代理人 linxiao gong
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