This invention relates to a category of tanshinone IIA derivate, this derivate connects with saturated fatty acid or unsaturated fatty acid at alpha-position of furan ring of tanshinone IIA, structural formula is formula I, among them, X is -(CHR)n-COOH,R=H or alkyl group whose carbon number is 1-8, n=0-8;or is -(CR=CH)n-COOH,R=H or alkyl group of which carbon number is 1-8, n=0-4. This tanshinone IIA derivate provides a dependable way for clinical application of tanshinone IIA, redeem the defect that acidity is excessively strong, stimulation is large, which is caused by sulfonic acid natrium injection of tanshinone IIA that is used as clinical medicine. |